Under the collaboration, the companies are developing antisense oligonucleotides (ASOs) for multiple neurodegenerative diseases
Cajal is responsible for nominating targets and mechanisms of action based on therapeutic insights from their discovery platform. (Credit: CDC on Unsplash)
Creyon Bio, a drug development company that engineers Oligonucleotide-Based Medicines (OBMs) with industry leading efficiency creating novel, best-in-class gene-centric medicines to treat rare and common diseases, and Cajal Neuroscience, (“Cajal”), a biotechnology company integrating disease-focused genetics and human data with state-of-the-art experimental capabilities to discover novel targets and therapeutics for neurodegeneration, today announced a partnership to develop novel OBMs for neurodegenerative diseases.
Under the collaboration, the companies are developing antisense oligonucleotides (ASOs) for multiple neurodegenerative diseases.
Cajal is responsible for nominating targets and mechanisms of action based on therapeutic insights from their discovery platform. Creyon is responsible for engineering oligonucleotide therapeutic candidates leveraging the powerful Creyon™ Platform, the first and only OBM platform designed to engineer for safety first, creating lead compounds with optimal pharmacological properties designed to minimize side effects.
Cajal will complete validation and IND-enabling studies of the lead therapeutic candidates. Creyon and Cajal have initiated and successfully advanced multiple programs, including one program nearing IND-enabling studies.
Chris Hart, Ph.D., Co-Founder, Chief Executive Officer, and President of Creyon Bio, said, “We are well positioned to accelerate the development of much needed therapies for patients with common neurodegenerative disorders by combining Cajal’s target identification capabilities with our platform designed to engineer safe, effective, and ultimately best-in-class compounds. This synergy between innovative target discovery capabilities and expert engineering of oligonucleotide-based medicines illustrates the strategic value of collaboration to advance new treatments for a myriad of diseases where there is high unmet need.”
“Oligonucleotides offer a promising modality for treating diseases of the central nervous system, including neurodegenerative disease. Using our human genetics platform we have identified novel targets that are well suited to oligonucleotide therapeutics. Creyon’s expertise in developing ASOs has been instrumental in our ability to prosecute on the targets we have identified. We look forward to continuing the collaboration as new targets continue to emerge from our platform,” said Ian Peikon, Ph.D., & Andrew Dervan, M.D., Co-Founders & Co-Chief Executive Officers of Cajal Neuroscience.
Source: Company Press Release